The Clark Center at Stanford
Molecular Bioengineering for Medicine and Biotechnology -- the Barron Group Biomimetic, Bioseparations, Bioconjugates 3-lobed navigation figure
Professor Annelise Barron
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The Barron lab is designing, creating and applying novel families of synthetic and biological polymers for applications in medicine and biotechnology. Our integrated approach to creating new and useful biomimetics and bioconjugates involves molecular design, chemical and/or biological synthesis, physical characterization, and finally, rigorous in vitro and in vivo testing of the new oligomers or polymers for their intended medical or biotechnological use.
A 3 lobed figure representing Biomimetics,  Bioconjugates and Bioseparations -- clicking on a lob will take you to that section. Biomimetics Section Bioconjugates Section Bioseperations Section
The work is highly interdisciplinary and collaborative, and variously intersects the domains of synthetic bioorganic chemistry, biophysics, protein mimicry or modification, polymer, biopolymer and hydrogel engineering, and finally the invention of new microscale bioseparations technologies. Common threads are polymer science and biological applications.
Desmarais SM, Leitner, T, Barron AE, “Quantitative experimental determination of primer-dimer formation risk by free-solution conjugate electrophoresis,” Electrophoresis 2012, 33, 483-491. pdf reprint
Wang XX, Albrecht JC, Lin JS, Barron AE, “Monodisperse, "Highly" Positively Charged Protein Polymer Drag-Tags Generated in an Intein-Mediated Purification System Used in Free-Solution Electrophoretic Separations of DNA,” Biomacromolecules 2012, 13, 117-123. pdf reprint
Hestekin CN, Lin JS, Senderowicz L, Jakupciak JP, O’Connell C, Rademaker A, Barron AE, “Blinded study determination of high sensitivity and specificity microchip electrophoresis-SSCP/HA to detect mutations in the p53 gene,” Electrophoresis 2011, 32, 2921-2929. pdf reprint
Sun M, Lin JS, Barron AE, “Ultrafast, efficient separations of large-sized dsDNA in a blended polymer matrix by microfluidic chip electrophoresis: A design of experiments approach,” Electrophoresis 2011, 32, 3233-3240. pdf reprint
Chongsiriwatana NP, Wetzler M, Barron AE, “Functional Synergy between Antimicrobial Peptoids and Peptides against Gram-Negative Bacteria,” Antimicrob Agents Chemother. 2011, 55, 5399-5402. pdf reprint
Brown NJ, Dohm MT, Bernardino de la Serna J, Barron AE, “Biomimetic N-terminal alkylation of peptoid analogues of surfactant protein C,” Biophys J. 2011, 101, 1076-85. pdf reprint
Lin JS, Albrecht JC, Meagher RJ, Wang X, Barron AE, “Completely monodisperse, highly repetitive proteins for bioconjugate capillary electrophoresis: development and characterization,” Biomacromolecules 2011, 12, 2275-84. pdf reprint
Niedringhaus TP, Milanova D, Kerby MB, Snyder MP, Barron AE, “Landscape of next-generation sequencing technologies,” Anal Chem. 2011, 83, 4327-41. pdf reprint
Albrecht JC, Kerby MB, Niedringhaus TP, Lin JS, Wang X, Barron AE, “Free-solution electrophoretic separations of DNA-drag-tag conjugates on glass microchips with no polymer network and no loss of resolution at increased electric field strength,” Electrophoresis 2011, 32, 1201-8. pdf reprint
Dohm MT, Kapoor R, Barron AE, “Peptoids: Bio-Inspired Polymers as Potential Pharmaceuticals,” Curr Pharm Des. 2011.
Kapoor R, Wadman MW, Dohm MT, Czyzewski AM, Spormann AM, Barron AE, “Antimicrobial peptoids are effective against Pseudomonas aeruginosa biofilms,” Antimicrob. Agents Chemother. 2011, 55, 3054-3057. pdf reprint
Kapoor R, Eimerman PR, Hardy JW, Cirillo JD, Contag CH, Barron AE, "Efficacy of antimicrobial peptoids Against Mycobacterium," Antimicrob. Agents Chemother. 2011, 55, 3058-3062. pdf reprint
Barron Lab Group Photo